I've never used VorpX , but I imagine that when depth buffer is inaccessible, regardless of the injector(ENB, ReShade, VORPX), 3D effects will not be possible.
ReShade was put on antivirus and anticheats whitelist , so whenever the game is competitive, the software automatically does not access the game depth buffer.
ReShade VR, for now, is just a hook for OVR, it still does not emulate the headtrack, so it's basically a softer replacement for Virtual Desktop and BIGSCREEN.
But for me (I have a GTX970), it's great because I do not need to play in 1080p, I can reduce the rendering to 75% and I get less aliasing than it would in "Video" mode in 1080p with 100% rendering.
And the best: I do not have to restart the HDM when I want to play with more FPS.
As soon as I finish Wolfenstein 2 (which uses only Vulkan, so it's not compatible with Injectors), I'm going to test Fallout 4 SE (it's almost certain to work as well as Skyrim with ReShadeVR).